English
norskBlar i forfatter "Filseth, Ole Magnus"
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Aspects of experimental cooling and rewarming with special reference to accidental hypothermia
(Doctoral thesis; Doktorgradsavhandling, 2012-08-17)Methods and aims We performed open, randomized, placebo-controlled experimental studies in intact, anesthetized pigs with the following main aims: Paper 1 To describe in detail the hemodynamic function with emphasis on left ventricular contractility during surface cooling, steady state severe hypothermia at 25°C, surface rewarming and in the post-hypothermic period of 2 h. Paper 2 1) To ... -
Cooling to hypothermic circulatory arrest by immersion vs. cardiopulmonary bypass (CPB): Worse outcome after rewarming in immersion cooled pigs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)Introduction: Cooling by cardiopulmonary bypass (CPB) to deep hypothermic cardiac arrest (HCA) for cardiac surgical interventions, followed by CPB-rewarming is performed on a routine basis with relatively low mortality. In contrast, victims of deep accidental hypothermia rewarmed with CPB generally have a much worse prognosis. Thus, we have developed an intact pig model to compare effects on ... -
Enhanced Blood Clotting After Rewarming From Experimental Hypothermia in an Intact Porcine Model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-29)Introduction: Due to functional alterations of blood platelets and coagulation enzymes at low temperatures, excessive bleeding is a well-recognized complication in victims of accidental hypothermia and may present a great clinical challenge. Still, it remains largely unknown if hemostatic function normalizes upon rewarming. The aim of this study was to investigate effects of hypothermia and rewarming ... -
Functional recovery after accidental deep hypothermic cardiac arrest: Comparison of different cardiopulmonary bypass rewarming strategies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-05)Introduction: Using a porcine model of accidental immersion hypothermia and hypothermic cardiac arrest (HCA), the aim of the present study was to compare effects of different rewarming strategies on CPB on need for vascular fluid supply, level of cardiac restitution, and cerebral metabolism and pressures.<p> <p>Materials and Methods: Totally sixteen healthy, anesthetized castrated male pigs were ... -
Integrating the clinical pharmacist into the emergency department interdisciplinary team: A study protocol for a multicentre trial applying a non-randomised stepped-wedge study design
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)Introduction: The ‘emergency department (ED) pharmacist’ is an integrated part of the ED interdisciplinary team in many countries, which have shown to improve medication safety and reduce costs related to hospitalisations. In Norway, few EDs are equipped with ED pharmacists, and research describing effects on patients has not been conducted. The aim of this study is to investigate the impact ... -
Integrating the clinical pharmacist into the emergency department interdisciplinary team: a study protocol for a multicentre trial applying a non-randomised stepped-wedge study design
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)Introduction - The ‘emergency department (ED) pharmacist’ is an integrated part of the ED interdisciplinary team in many countries, which have shown to improve medication safety and reduce costs related to hospitalisations. In Norway, few EDs are equipped with ED pharmacists, and research describing effects on patients has not been conducted. The aim of this study is to investigate the impact of ...
